Separable roles for Microprocessor and its cofactors ERH and SAFB1/2 during microRNA cluster assistance.

Renfu Shang, Niko Popitsch, Seungjae Lee, Stefan L. Ameres and Eric C. Lai.

Genes & Development 40, 517. doi: 10.1101/gad.353316.125

Human DICER1 hotspot mutation induces both loss and gain of miRNA function.

David Jee*, Seungjae Lee*, Dapeng Yang, Robert Rickert, Renfu Shang, Danwei Huangfu and Eric C. Lai.

Nature Structural & Molecular Biology 32, 2553. doi: 10.1038/s41594-025-01701-7

Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing.

Seungjae Lee, Sangmi Lee, Robert Desnick, Makiko Yasuda, and Eric C. Lai.

Science 386, 1427. doi: 10.1126/science.adp9388

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution.

Tzu-Chiao Lu, Maria Brbić, Ye-Jin Park, Tyler Jackson, Jiaye Chen, Sai Saroja Kolluru, Yanyan Qi, Nadja Sandra Katheder, Xiaoyu Tracy Cai, Seungjae Lee, Yen-Chung Chen, Niccole Auld, Doug Welsch, Samuel D'Souza, Angela Oliveira Pisco, Robert C. Jones, Jure Leskovec, Eric C. Lai, Hugo J. Bellen, Liqun Luo, Heinrich Jasper, Stephen R. Quake, and Hongjie Li.

Science 380, 1145. doi: 10.1126/science.adg0934

Promiscuous splicing-derived hairpins are dominant substrates of tailing-mediated defense of miRNA biogenesis in mammals.

Seungjae Lee, David Jee, Sid Srivastava, Acong Yang, Abhinav Ramidi, Renfu Shang, Diane Bortolamiol-Becet, Sebastian Pfeffer, Shuo Gu, Jiayu Wen, and Eric C. Lai.

Cell Reports 42(2), 112111. doi: 10.1016/j.celrep.2023.112111

Diverse cell-specific patterns of alternative polyadenylation in Drosophila.

Seungjae Lee, Yen-Chung Chen, FCA Consortium, Austin E. Gillen, J. Matthew Taliaferro, Bart Deplancke, Hongjie Li, and Eric C. Lai.

Nature Communications 13, 5372. doi: 10.1038/s41467-022-32305-0

ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing.

Seungjae Lee, Lu Wei, Binglong Zhang, Raeann Goering, Sonali Majumdar, Jiayu Wen, J. Matthew Taliaferro, and Eric C. Lai.

PLoS Genetics 17(4): e1009439. doi: 10.1371/journal.pgen.1009439

Overlapping activities of ELAV/Hu family RNA binding proteins specify the extended neuronal 3’ UTR landscape in Drosophila.

Lu Wei*, Seungjae Lee*, Sonali Majumdar, Binglong Zhang, Piero Sanfilippo, Brian Joseph, Pedro Miura, Matthias Soller, and Eric C. Lai.

Molecular Cell 80, 140. doi: 10.1016/j.molcel.2020.09.007. doi: 10.1016/j.ibmb.2020.103415

Roles for Drosophila Cap1 2’-O-ribose methyltransferase in the small RNA silencing pathway associated with Argonaute 2.

Seungjae Lee, Jae-Sang Hong, Do-Hwan Lim, and Young Sik Lee.

Insect Biochemistry and Molecular Biology 123, 103415. doi: 10.1016/j.ibmb.2020.103415

The conserved microRNA miR-8-3p coordinates the expression of V-ATPase subunits to regulate ecdysone biosynthesis for Drosophila metamorphosis.

Do-Hwan Lim*, Seungjae Lee*, Min-Seok Choi, Jee Yun Han, Youngmo Seong, Dokyun Na, Young-Soo Kwon, Kyoung Sang Cho, KyeongJin Kang, and Young Sik Lee.

The FASEB Journal 34, 6449. doi: 10.1096/fj.201901516R.

MicroRNA miR-252 targets mbt to control the developmental growth of Drosophila.

Do-Hwan Lim*, Seungjae Lee*, Jee Yun Han*, Min-Seok Choi, Jae-Sang Hong, and Young Sik Lee.

Insect Molecular Biology 28, 444. doi: 10.1111/imb.12562

Ecdysone-responsive microRNA-252-5p controls the cell cycle by targeting Abi in Drosophila.

Do-Hwan Lim*, Seungjae Lee*, Jee Yun Han, Min-Seok Choi, Jae-Sang Hong, Youngmo Seong, Young-Soo Kwon, and Young Sik Lee.

The FASEB Journal 32, 4519. doi: 10.1096/fj.201701185RR